Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA8 | P11142 | 3/20 | 0.66 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.66 |
| ▸ | FBP1 | P09467 | 1/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | HBB | P68871 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | GAPDH | P04406 | 1/20 | 0.58 |
| ▸ | ENTPD1 | P49961 | 1/20 | 0.58 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.57 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.56 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.56 |
| ▸ | ADK | P55263 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 8-Chloroadenosine SCHEMBL19668313 | 0.94 | HSPA8 (0.71) | HSPA8HSPA5FBP1RXFP1LMNA | |
| 8-Chloroadenosine SCHEMBL10531116 | 0.94 | HSPA8 (0.71) | HSPA8HSPA5FBP1RXFP1LMNA | |
| 8-Chloroadenosine SCHEMBL19668314 | 0.93 | HSPA8 (0.69) | HSPA8HSPA5FBP1RXFP1LMNA | |
| 8-Chloroadenosine SCHEMBL987731 | 0.91 | HSPA8 (0.78) | HSPA8HSPA5RXFP1LMNATP53 | |
| 8-Chloroadenosine SCHEMBL26788558 | 0.91 | HSPA8 (0.78) | HSPA8HSPA5RXFP1LMNATP53 | |
| 8-Chloroadenosine SCHEMBL19680324 | 0.91 | HSPA8 (0.78) | HSPA8HSPA5RXFP1LMNATP53 | |
| 8-Chloroadenosine SCHEMBL987728 | 0.91 | HSPA8 (0.78) | HSPA8HSPA5RXFP1LMNATP53 | |
| 8-Chloroadenosine SCHEMBL31064773 | 0.91 | HSPA8 (0.78) | HSPA8HSPA5RXFP1LMNATP53 | |
| SCHEMBL9752397 | 0.88 | ENTPD1 (0.74) | ENTPD1 | |
| SCHEMBL9752399 | 0.88 | ENTPD1 (0.74) | ENTPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991000346-A1 | POLYNUCLEOTIDE PHOSPHORYLASE IMMOBILIZED ON TRIS(HYDROXYMETHYL)METHYLACRYLAMIDE POLYMER BEADS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-01-10 | — | — | WO | disclosed |
| EP-0346865-A2 | Polynucleotide phosphorylase immobilized on epoxy-activated beads | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1989-12-20 | — | — | EP | disclosed |