Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877820 | 0.81 | NAAA (0.43) | HCRTR1HCRTR2NAAA | |
| SCHEMBL29196393 | 0.73 | HRH3 (0.44) | HRH3CYP1A2ACHESLC6A4 | |
| SCHEMBL8669331 | 0.71 | BCHE (0.51) | HRH3CYP1A2ACHESLC6A4 | |
| SCHEMBL12126061 | 0.70 | HRH3 (0.47) | HRH3ACHE | |
| SCHEMBL1581891 | 0.70 | GRIN2D (0.50) | HRH3CYP1A2ACHE | |
| SCHEMBL8669223 | 0.68 | BCHE (0.59) | HRH3CYP1A2ACHESLC6A4 | |
| SCHEMBL15599122 | 0.68 | TSHR (0.46) | HRH3CYP1A2NAAA | |
| SCHEMBL29196400 | 0.67 | HRH3 (0.47) | HRH3CYP1A2NAAAACHESLC6A4 | |
| SCHEMBL1612373 | 0.67 | HCRTR1 (0.58) | HCRTR1HCRTR2 | |
| SCHEMBL1612378 | 0.67 | HCRTR1 (0.58) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |