Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.68 |
| ▸ | BACE1 | P56817 | 4/20 | 0.68 |
| ▸ | MAOB | P27338 | 2/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.58 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320471 | 0.86 | GSK3B (0.52) | GSK3BBACE1MAOBABCG2ALOX5 | |
| SCHEMBL9344837 | 0.83 | GSK3B (0.76) | GSK3BBACE1MAOBABCG2NPC1 | |
| SCHEMBL9344834 | 0.83 | GSK3B (0.76) | GSK3BBACE1MAOBABCG2NPC1 | |
| SCHEMBL7999153 | 0.83 | GSK3B (0.83) | GSK3BBACE1MAOBABCG2NPC1 | |
| SCHEMBL527828 | 0.83 | GSK3B (0.80) | GSK3BBACE1MAOBABCG2NPC1 | |
| SCHEMBL527827 | 0.83 | GSK3B (0.80) | GSK3BBACE1MAOBABCG2NPC1 | |
| SCHEMBL8740053 | 0.83 | GSK3B (0.80) | GSK3BBACE1MAOBABCG2NPC1 | |
| SCHEMBL7999149 | 0.83 | GSK3B (0.83) | GSK3BBACE1MAOBABCG2NPC1 | |
| Hydrochloric Acid SCHEMBL7054738 | 0.81 | GSK3B (0.78) | GSK3BBACE1MAOBABCG2NPC1 | |
| SCHEMBL9735221 | 0.81 | BACE1 (0.81) | GSK3BBACE1MAOBABCG2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |