Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ADK | P55263 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877398 | 0.89 | MEN1 (0.53) | PTGIRLMNATP53GFERKDM4E | |
| SCHEMBL9877271 | 0.85 | GFER (0.50) | PTGIRALDH1A1AURKAAURKBGFER | |
| SCHEMBL5837713 | 0.79 | MAPK14 (0.44) | LMNATP53AURKAAURKBGFER | |
| SCHEMBL9877217 | 0.79 | ACHE (0.54) | PTGIRALOX15TP53ALDH1A1KDM4E | |
| SCHEMBL10560612 | 0.78 | ALDH1A1 (0.48) | LMNATP53ALDH1A1KDM4E | |
| SCHEMBL9877607 | 0.77 | KMT2A (0.49) | PTGIRALOX15ALDH1A1RAB9A | |
| Fezolamine SCHEMBL5783220 | 0.77 | PTGIR (0.58) | PTGIRKDM4E | |
| Fezolamine SCHEMBL121816 | 0.77 | PTGIR (0.58) | PTGIRKDM4E | |
| Fezolamine SCHEMBL122598 | 0.76 | PTGIR (0.58) | PTGIRLMNAALDH1A1CYP2C19KDM4E | |
| Fezolamine SCHEMBL122599 | 0.76 | PTGIR (0.58) | PTGIRLMNAALDH1A1CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988725-A | Cardiovascular disorders, antiarrhythmia agents | STERLING DRUG INC. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0299407-B1 | 1H-PYRAZOLE-1-ALKANAMIDES AND PREPARATION USEFUL AS ANTIARRHYTHMIC AGENTS | STERLING DRUG INC. (US) | 1990-10-24 | — | — | EP | disclosed |
| EP-0388654-A2 | Azole-1-alkanamides as antiarrhythmic agents and preparation thereof | STERLING DRUG INC. (US) | 1990-09-26 | — | — | EP | disclosed |
| US-4916150-A | 1H-pyrazole-1-alkanamines antiarrhythmic compositions and use | STERLING DRUG INC. (US) | 1990-04-10 | — | — | US | disclosed |
| US-4870095-A | 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use | STERLING DRUG, INC. (US) | 1989-09-26 | — | — | US | disclosed |
| EP-0299407-A1 | 1H-pyrazole-1-alkanamides and preparation useful as antiarrhythmic agents | STERLING DRUG INC. (US) | 1989-01-18 | — | — | EP | disclosed |