Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1353883 | 1.00 | DNM1 (0.45) | DNM1CA12CA1CA9TSHR | |
| Bromide SCHEMBL466549 | 1.00 | DNM1 (0.45) | DNM1CA12CA1CA9TSHR | |
| Bromide SCHEMBL1353881 | 1.00 | DNM1 (0.45) | DNM1CA12CA1CA9TSHR | |
| Ethane SCHEMBL27638602 | 0.96 | DNM1 (0.43) | DNM1CA12CA1CA9TSHR | |
| Bromide SCHEMBL29048086 | 0.96 | DNM1 (0.43) | DNM1CA12CA1CA9TSHR | |
| Hexane SCHEMBL28009287 | 0.96 | DNM1 (0.50) | DNM1CA12CA1CA9TSHR | |
| Hexane SCHEMBL28564868 | 0.96 | DNM1 (0.50) | DNM1CA12CA1CA9TSHR | |
| Bromide SCHEMBL8369863 | 0.96 | DNM1 (0.43) | DNM1CA12CA1CA9TSHR | |
| SCHEMBL3904839 | 0.96 | TSHR (0.46) | DNM1CA12CA1CA9TSHR | |
| SCHEMBL27566038 | 0.96 | TSHR (0.46) | DNM1CA12CA1CA9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991003449-A1 | ISOMERIZATION OF ALK-2-ENYL ETHERS | GAF CHEMICALS CORPORATION (US) | 1991-03-21 | — | — | WO | disclosed |