Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | GRK2 | P25098 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877236 | 0.84 | CA1 (0.63) | FFAR1MEN1KMT2AHIF1A | |
| SCHEMBL2185809 | 0.82 | FFAR1 (0.70) | HDAC8HDAC6FFAR1KMT2AHIF1A | |
| SCHEMBL27845742 | 0.79 | HDAC8 (0.58) | HDAC8HDAC11HDAC6FFAR1MEN1 | |
| SCHEMBL9877319 | 0.78 | KCNK3 (0.67) | MEN1KMT2A | |
| SCHEMBL15458722 | 0.77 | HIF1A (0.67) | HDAC8HDAC6FFAR1KMT2AHIF1A | |
| SCHEMBL15576275 | 0.77 | HDAC8 (0.59) | HDAC8HDAC11HDAC6FFAR1KMT2A | |
| SCHEMBL10055040 | 0.77 | FFAR1 (0.68) | FFAR1HIF1AMRGPRX4PPARA | |
| SCHEMBL10411601 | 0.77 | FFAR1 (0.50) | HDAC8HDAC6FFAR1HIF1A | |
| SCHEMBL6846999 | 0.77 | HDAC8 (0.55) | HDAC8HDAC11HDAC6FFAR1KMT2A | |
| SCHEMBL10106419 | 0.76 | MAPT (0.65) | HDAC8HDAC11MEN1KMT2AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |