Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 7/20 | 0.67 |
| ▸ | KCNK9 | Q9NPC2 | 7/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877204 | 0.84 | CACNA1B (0.65) | RAB9AKMT2AMEN1POLBSIRT1 | |
| SCHEMBL7500312 | 0.82 | KMT2A (0.84) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| SCHEMBL2298254 | 0.81 | KCNK3 (1.00) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| SCHEMBL679144 | 0.80 | KMT2A (0.90) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| SCHEMBL7745692 | 0.79 | KCNK3 (0.80) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL2106175 | 0.78 | KMT2A (0.87) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| SCHEMBL7745302 | 0.78 | KCNK3 (0.79) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| SCHEMBL14715827 | 0.78 | KCNK3 (0.92) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| SCHEMBL14715912 | 0.78 | KCNK3 (0.92) | KCNK3KCNK9RAB9AKMT2AMEN1 | |
| SCHEMBL9877862 | 0.78 | HDAC8 (0.53) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |