Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | ALPL | P05186 | 1/20 | 0.59 |
| ▸ | ALPI | P09923 | 1/20 | 0.59 |
| ▸ | ALPG | P10696 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | PDE9A | O76083 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9878603 | 0.91 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2NPC1RAB9AALPL | |
| SCHEMBL9878904 | 0.82 | MAPT (0.75) | MAPTSMN1; SMN2NPC1RAB9AALPL | |
| SCHEMBL9878731 | 0.82 | MEN1 (0.51) | MAPTSMN1; SMN2NPC1RAB9AALPL | |
| SCHEMBL9878442 | 0.78 | MEN1 (0.53) | MAPTSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL9878899 | 0.78 | MEN1 (0.53) | MAPTSMN1; SMN2NPC1RAB9AALPL | |
| SCHEMBL9879015 | 0.76 | KMT2A (0.60) | MAPTSMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL9776663 | 0.73 | KMT2A (0.65) | MAPTSMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL31087175 | 0.73 | HPGD (1.00) | HPGDPKML3MBTL1 | |
| SCHEMBL16981701 | 0.72 | PDE9A (1.00) | PDE9A | |
| SCHEMBL9878600 | 0.71 | MEN1 (0.45) | MAPTSMN1; SMN2NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018887-A1 | DIAMINOPYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1991-12-12 | — | — | WO | disclosed |