Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | PDE9A | O76083 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 3/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9878442 | 0.91 | MEN1 (0.53) | MEN1KMT2APDE9AMAPTLMNA | |
| SCHEMBL9878956 | 0.79 | ALDH1A1 (0.50) | KMT2AMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL9878603 | 0.78 | SMN1; SMN2 (0.56) | MEN1KMT2APDE9AMAPTLMNA | |
| SCHEMBL9879427 | 0.76 | MEN1 (0.51) | MEN1KMT2APDE9AMAPTLMNA | |
| SCHEMBL9878901 | 0.74 | EGFR (0.49) | MEN1KMT2AMAPTLMNANPC1 | |
| SCHEMBL9879085 | 0.73 | MEN1 (0.53) | MEN1KMT2APDE9AMAPTLMNA | |
| SCHEMBL9878449 | 0.71 | MAPT (0.66) | MEN1KMT2APDE9AMAPTLMNA | |
| SCHEMBL2495418 | 0.69 | MAPT (0.49) | KMT2AMAPTLMNATP53NPC1 | |
| SCHEMBL9879014 | 0.69 | KMT2A (0.60) | MEN1KMT2APDE9AMAPTNPC1 | |
| SCHEMBL880472 | 0.67 | NPC1 (0.68) | MAPTLMNATP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991018887-A1 | DIAMINOPYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1991-12-12 | — | — | WO | disclosed |