SCHEMBL9878587

SCHEMBL9878587

CCNCc1cc(OC)c2c(c1)C(=O)c1cc(OC)cc(OC)c1C2=O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.65
CYP1A2 P05177 1/20 0.65
CYP3A4 P08684 1/20 0.65
ELANE P08246 4/20 0.52
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
HTR1A P08908 1/20 0.40
HTR1D P28221 1/20 0.40
HTR1B P28222 1/20 0.40
HTR2A P28223 1/20 0.40
HTR2C P28335 1/20 0.40
HTR7 P34969 1/20 0.40
HTR2B P41595 1/20 0.40
HTR5A P47898 1/20 0.40
HTR6 P50406 1/20 0.40
KDM4E B2RXH2 2/20 0.40
GLA P06280 1/20 0.40
MAPT P10636 1/20 0.40
HPGD P15428 1/20 0.40
ALOX15 P16050 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9877882 0.86 ALDH1A1 (0.60) ALDH1A1CYP1A2CYP3A4ELANEMEN1
SCHEMBL9877592 0.86 ALDH1A1 (0.60) ALDH1A1CYP1A2CYP3A4ELANEMEN1
SCHEMBL9877590 0.84 ELANE (0.51) ALDH1A1CYP1A2CYP3A4ELANEMEN1
SCHEMBL9878285 0.83 ELANE (0.58) ALDH1A1CYP1A2CYP3A4ELANEMEN1
SCHEMBL9878499 0.81 ALDH1A1 (0.75) ALDH1A1CYP1A2CYP3A4ELANEKDM4E
SCHEMBL16226679 0.81 ALDH1A1 (1.00) ALDH1A1CYP1A2CYP3A4ELANEKDM4E
SCHEMBL9878005 0.78 ALDH1A1 (0.65) ALDH1A1CYP1A2CYP3A4ELANEHTR1A
SCHEMBL27820157 0.78 ALDH1A1 (0.69) ALDH1A1CYP1A2CYP3A4ELANEKDM4E
SCHEMBL28005845 0.78 ALDH1A1 (0.69) ALDH1A1CYP1A2CYP3A4ELANEHTR1A
SCHEMBL16225747 0.76 ALDH1A1 (0.61) ALDH1A1CYP1A2CYP3A4ELANEMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4966918-A ANTICARCINOGENIC AGENTS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1990-10-30 US claimed
WO-1990008759-A1 DERIVATIVES OF CHRYSOPHANOL SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1990-08-09 WO claimed
US-5053431-A Antitumor-anticarcinogenic agents SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1991-10-01 US disclosed
US-4966918-A ANTICARCINOGENIC AGENTS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1990-10-30 US disclosed
WO-1990008759-A1 DERIVATIVES OF CHRYSOPHANOL SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1990-08-09 WO disclosed