SCHEMBL987937

SCHEMBL987937

CC(C)(C)OC(=O)COc1ccc(CNCCO[Si](C)(C)C(C)(C)C)cc1-c1cccc(C#N)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 3/20 0.43
SCN8A Q9UQD0 1/20 0.36
CD274 Q9NZQ7 5/20 0.36
PDCD1 Q15116 4/20 0.36
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 2/20 0.35
CYP2D6 P10635 2/20 0.35
CYP2C19 P33261 2/20 0.35
PTPN1 P18031 1/20 0.35
KDM4E B2RXH2 1/20 0.35
GAA P10253 1/20 0.35
CLK4 Q9HAZ1 3/20 0.35
DYRK1A Q13627 2/20 0.35
VNN1 O95497 2/20 0.35
EGLN1 Q9GZT9 1/20 0.35
USP2 O75604 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
TP53 P04637 1/20 0.34
CYP2C9 P11712 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12948815 0.85 PTGDR2 (0.42) PTGDR2SCN8ACD274PDCD1CYP1A2
SCHEMBL987174 0.78 KCNA5 (0.37) PTGDR2ALDH1A1LMNA
SCHEMBL990554 0.76 PTGDR2 (0.53) PTGDR2CYP2C19PTPN1KDM4EEGLN1
SCHEMBL988484 0.76 PTGDR2 (0.43) PTGDR2CYP1A2CYP3A4CYP2D6CYP2C19
SCHEMBL12948816 0.75 PDPK1 (0.38) PTGDR2SCN8AKDM4EGAAALDH1A1
SCHEMBL2771530 0.72 PTGDR2 (0.40) PTGDR2PTPN1VNN1ACLYAR
SCHEMBL14885448 0.70 PTGDR2 (0.42) PTGDR2PTPN1VNN1ALDH1A1LMNA
SCHEMBL988942 0.70 PTGDR2 (0.42) PTGDR2PTPN1KDM4EGAAALDH1A1
SCHEMBL406503 0.69 SCN8A (0.51) SCN8ACD274PDCD1VNN1LMNA
SCHEMBL12948882 0.69 PTGDR2 (0.43) PTGDR2CYP2C19PTPN1CYP2C9ACLY

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011002814-A2 BIARYL OXYACETIC ACID COMPOUNDS LIGAND PHARMACEUTICALS INC. (US) 2011-01-06 WO disclosed