SCHEMBL9879540

SCHEMBL9879540

C=CCOC(=O)C(O)(CCC)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.45
SCN1A P35498 3/20 0.45
SCN2A Q99250 3/20 0.45
SCN3A Q9NY46 3/20 0.45
TSHR P16473 4/20 0.43
LMNA P02545 3/20 0.43
CYP2D6 P10635 3/20 0.43
CYP1A2 P05177 2/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
NFKB1 P19838 1/20 0.43
MTOR P42345 1/20 0.43
RAB9A P51151 1/20 0.43
SIGMAR1 Q99720 1/20 0.43
KDM4E B2RXH2 3/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
HSD17B10 Q99714 2/20 0.42
NPSR1 Q6W5P4 2/20 0.42
NR1I2 O75469 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11783872 0.85 TSHR (0.47) CYP3A4SCN1ASCN2ASCN3ATSHR
SCHEMBL9879134 0.84 SCN1A (0.44) CYP3A4SCN1ASCN2ASCN3ATSHR
SCHEMBL10745489 0.83 PIN1 (0.50) CYP3A4SCN1ASCN2ASCN3ATSHR
SCHEMBL6472435 0.82 ALDH1A1 (0.50) CYP3A4SCN1ASCN2ASCN3ATSHR
SCHEMBL11775522 0.81 CYP3A4 (0.46) CYP3A4TSHRCYP1A2CYP2C9CYP2C19
SCHEMBL9879410 0.79 SCN1A (0.40) CYP3A4SCN1ASCN2ASCN3ATSHR
SCHEMBL1502420 0.78 CYP3A4 (0.50) CYP3A4TSHRLMNACYP2C19KDM4E
SCHEMBL11329310 0.78 KCNN4 (0.56) CYP3A4SCN1ASCN2ASCN3ATSHR
SCHEMBL751119 0.78 CYP3A4 (0.53) CYP3A4TSHRLMNARAB9AKDM4E
SCHEMBL28003868 0.78 CYP3A4 (0.53) CYP3A4TSHRLMNARAB9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5008285-A Antiarthritic agent with low gastric irritability side effect HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1991-04-16 US disclosed
EP-0159684-B1 (6,11-DIHYDRO-11-OXODIBENZ(B,E)OXEPINYL)PENTANOIC ACIDS AND DERIVATIVES, A PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1989-09-27 EP disclosed