Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.53 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 3/20 | 0.47 |
| ▸ | BRS3 | P32247 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9873276 | 0.94 | AGTR1 (0.51) | AGTR1AGTR2PPARGBRS3 | |
| SCHEMBL9879521 | 0.88 | AGTR1 (0.49) | AGTR1AGTR2PPARGBRS3 | |
| SCHEMBL9879625 | 0.87 | AGTR1 (0.47) | AGTR1AGTR2PPARG | |
| SCHEMBL9879662 | 0.86 | AGTR2 (0.59) | AGTR1AGTR2 | |
| SCHEMBL9873028 | 0.86 | AGTR1 (0.48) | AGTR1AGTR2PPARG | |
| SCHEMBL9875199 | 0.84 | AGTR1 (0.56) | AGTR1AGTR2PPARGBRS3 | |
| SCHEMBL9874749 | 0.83 | AGTR1 (0.49) | AGTR1AGTR2PPARG | |
| SCHEMBL9872109 | 0.83 | AGTR1 (0.47) | AGTR1AGTR2PPARGBRS3 | |
| SCHEMBL9871848 | 0.81 | AGTR1 (0.47) | AGTR1AGTR2PPARG | |
| SCHEMBL9872843 | 0.81 | AGTR1 (0.62) | AGTR1AGTR2PPARGBRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0206741-B1 | LEUKOTRIENE ANTAGONISTS | MERCK FROSST CANADA INC. (CA) | 1991-04-10 | — | — | EP | claimed |
| WO-1991019715-A1 | 1H-SUBSTITUTED-IMIDAZO[4,5-d]PYRIDAZINE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-12-26 | — | — | WO | disclosed |