Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TFPI2 | P48307 | 7/20 | 0.71 |
| ▸ | PPP5C | P53041 | 2/20 | 0.71 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.71 |
| ▸ | NPY4R | P50391 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lb-100 SCHEMBL13311584 | 0.83 | TFPI2 (1.00) | TFPI2PPP5CPPP2CANPY4RHTT | |
| Lb-100 SCHEMBL9880148 | 0.83 | TFPI2 (1.00) | TFPI2PPP5CPPP2CANPY4RHTT | |
| Lb-100 SCHEMBL2832350 | 0.83 | TFPI2 (1.00) | TFPI2PPP5CPPP2CANPY4RHTT | |
| Lb-100 SCHEMBL26377801 | 0.83 | TFPI2 (1.00) | TFPI2PPP5CPPP2CANPY4RHTT | |
| Lb-100 SCHEMBL19512780 | 0.83 | TFPI2 (1.00) | TFPI2PPP5CPPP2CANPY4RHTT | |
| Lb-100 SCHEMBL19501013 | 0.83 | TFPI2 (1.00) | TFPI2PPP5CPPP2CANPY4RHTT | |
| Lb-100 SCHEMBL12390164 | 0.83 | TFPI2 (1.00) | TFPI2PPP5CPPP2CANPY4RHTT | |
| SCHEMBL12390225 | 0.83 | TFPI2 (0.50) | TFPI2PPP5CPPP2CANPY4R | |
| SCHEMBL9880161 | 0.82 | TFPI2 (0.74) | TFPI2PPP5CPPP2CANPY4RHTT | |
| SCHEMBL13001884 | 0.82 | TFPI2 (0.49) | TFPI2PPP5CPPP2CANPY4RLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329719-B2 | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases | LIXTE BIOTECHNOLOGY, INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-20120135522-A1 | METHODS OF MODULATING CELL REGULATION BY INHIBITING P53 | LIXTE BIOTECHNOLOGY, INC. | 2012-05-31 | — | — | US | disclosed |
| US-20110287537-A1 | NEUROPROTECTIVE AGENTS FOR THE PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES | LIXTE BIOTECHNOLOGY, INC. | 2011-11-24 | — | — | US | disclosed |
| US-20100029683-A1 | Methods for regulating cell mitosis by inhibiting serine/threonine phosphateses | LIXTE BIOTECHNOLOGY, INC. | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029683-A1 | Methods for regulating cell mitosis by inhibiting serine/threonine phosphateses | PSPH, PPP5C, BUB1B | TFPI2 2409/4885PPP5C 2/4885PPP2CA 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.