Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | MAP3K14 | Q99558 | 6/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PKLR | P30613 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1516816 | 0.89 | PIK3CA (0.39) | PIK3CAPIK3CBPIK3CDPIK3R1MAOB | |
| SCHEMBL12535860 | 0.80 | PIK3CA (0.52) | PIK3CAPIK3CBMAP3K14PIK3CDPIK3R1 | |
| SCHEMBL989361 | 0.80 | PIK3CA (0.45) | PIK3CAPIK3CBMAP3K14PIK3CDPIK3R1 | |
| SCHEMBL988266 | 0.79 | PIK3CA (0.39) | PIK3CAPIK3CBMAP3K14PIK3CDPIK3R1 | |
| SCHEMBL11618347 | 0.77 | PKM (0.45) | PIK3CAPIK3CBMAOBPKMPKLR | |
| SCHEMBL1265517 | 0.72 | MAOB (0.53) | PIK3CAPIK3CBMAOBGRM5PKM | |
| SCHEMBL1484768 | 0.72 | PIK3CA (0.52) | PIK3CAPIK3CBPIK3CDMAOBGRM5 | |
| SCHEMBL4065800 | 0.69 | PIK3CA (0.45) | PIK3CAPIK3CBMAP3K14PIK3CDPIK3R1 | |
| SCHEMBL988559 | 0.69 | PIK3CA (0.46) | PIK3CAPIK3CBMAP3K14MAOBGRM5 | |
| SCHEMBL3492241 | 0.68 | PRKCI (0.47) | PIK3CAPIK3CBMAOBPKMPKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |