Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989505 | 0.90 | PIK3CA (0.35) | LMNAMAPTHTTBLM | |
| SCHEMBL988556 | 0.83 | LMNA (0.36) | LMNAMAPTHTTBLMMAOB | |
| SCHEMBL1516943 | 0.82 | LMNA (0.37) | LMNAMAPTHTTBLMMAOB | |
| SCHEMBL1516787 | 0.78 | PRMT5 (0.34) | LMNAMAPTHTTBLMMAOB | |
| SCHEMBL1516820 | 0.78 | PRMT5 (0.35) | LMNAMAPTHTTBLMMAOB | |
| SCHEMBL1516808 | 0.78 | LMNA (0.37) | LMNAMAPTHTTBLMMAOB | |
| SCHEMBL1516837 | 0.78 | LMNA (0.37) | LMNAMAPTHTTBLMMAOB | |
| SCHEMBL4061855 | 0.78 | LMNA (0.34) | LMNAMAPTHTTBLMMAOB | |
| SCHEMBL1516826 | 0.78 | LMNA (0.34) | LMNAMAPTHTTBLMMAOB | |
| SCHEMBL988493 | 0.77 | PRMT5 (0.35) | LMNAMAPTHTTBLMMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |