Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988754 | 0.90 | LMNA (0.34) | LMNAMAPTHTTBLM | |
| SCHEMBL989248 | 0.80 | HDAC3 (0.34) | PIK3CAPIK3CBPIK3CGPIK3CDLMNA | |
| SCHEMBL989471 | 0.78 | NOTUM (0.34) | PIK3CAPIK3CBPIK3CGPIK3CDLMNA | |
| SCHEMBL989459 | 0.77 | PIK3CA (0.34) | PIK3CAPIK3CBPIK3CGPIK3CDLMNA | |
| SCHEMBL15200696 | 0.75 | RAB9A (0.33) | PIK3CAPIK3CBPIK3CGPIK3CDLMNA | |
| SCHEMBL988556 | 0.73 | LMNA (0.36) | LMNAMAPTHTTBLM | |
| SCHEMBL1516808 | 0.72 | LMNA (0.37) | PIK3CAPIK3CBPIK3CGPIK3CDLMNA | |
| SCHEMBL1516837 | 0.72 | LMNA (0.37) | PIK3CAPIK3CBPIK3CGPIK3CDLMNA | |
| SCHEMBL988657 | 0.71 | NPC1 (0.35) | PIK3CAPIK3CBPIK3CGPIK3CDMAPT | |
| SCHEMBL1516943 | 0.71 | LMNA (0.37) | PIK3CAPIK3CBPIK3CGPIK3CDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009123971-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-10-08 | — | — | WO | disclosed |