Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | PRKDC | P78527 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989977 | 0.89 | PIK3CA (0.51) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL1516834 | 0.77 | PRMT5 (0.34) | PIK3CAMAOB | |
| SCHEMBL988531 | 0.77 | PIK3CA (0.89) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL1516817 | 0.76 | PRMT5 (0.34) | MAOB | |
| SCHEMBL990106 | 0.75 | PIK3CA (0.58) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL988493 | 0.75 | PRMT5 (0.35) | MAOB | |
| SCHEMBL1516787 | 0.74 | PRMT5 (0.34) | PIK3CAMAOB | |
| SCHEMBL15663478 | 0.74 | PIK3CA (0.52) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL989428 | 0.73 | TAS1R3 (0.41) | PIK3CAPIK3CB | |
| SCHEMBL1516933 | 0.72 | MAPT (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |