Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988430 | 0.89 | LMNA (0.36) | MAPTPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL1516817 | 0.81 | PRMT5 (0.34) | MAPTHTTLMNAPRMT5WDR77 | |
| SCHEMBL988493 | 0.79 | PRMT5 (0.35) | MAPTHTTLMNAPRMT5WDR77 | |
| SCHEMBL1516787 | 0.78 | PRMT5 (0.34) | MAPTHTTMEN1KMT2ALMNA | |
| SCHEMBL4061855 | 0.76 | LMNA (0.34) | MAPTHTTMEN1KMT2ANPC1 | |
| SCHEMBL1516834 | 0.74 | PRMT5 (0.34) | PRMT5WDR77PIK3CA | |
| SCHEMBL988653 | 0.74 | PPARA (0.38) | MAPTHTTPOLBALDH1A1MEN1 | |
| SCHEMBL989248 | 0.74 | HDAC3 (0.34) | MAPTHTTNPC1LMNARAB9A | |
| SCHEMBL989472 | 0.73 | PIK3CA (0.52) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL988973 | 0.73 | PIK3CA (0.53) | PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276767-A1 | BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |