Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 18/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1F | P30939 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9107117 | 0.82 | PIK3C3 (0.45) | PIK3C3HTR1AHTR1DHTR1FCDC7 | |
| SCHEMBL622929 | 0.79 | ROCK2 (0.34) | PIK3C3HTR1AHTR1DHTR1F | |
| SCHEMBL9107106 | 0.75 | PIK3C3 (0.38) | PIK3C3HTR1AHTR1DHTR1FCDC7 | |
| SCHEMBL9889941 | 0.73 | PIK3C3 (0.36) | PIK3C3 | |
| SCHEMBL9104256 | 0.72 | PIK3C3 (0.40) | PIK3C3 | |
| SCHEMBL9890493 | 0.72 | WDR5 (0.36) | — | |
| SCHEMBL9108830 | 0.72 | KDM4E (0.36) | PIK3C3 | |
| SCHEMBL9888610 | 0.68 | S1PR4 (0.38) | PIK3C3 | |
| SCHEMBL9108495 | 0.65 | PIK3C3 (0.35) | PIK3C3HTR1AHTR1DHTR1F | |
| SCHEMBL15072386 | 0.65 | PIK3C3 (0.38) | PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859768-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20120142732-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142732-A1 | HETEROARYLS AND USES THEREOF | PIK3R4, PIK3C2B, PIK3R1 | PIK3C3 52/4885HTR1A 1126/4885HTR1D 1447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.