Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 4/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9891883 | 1.00 | MAPT (0.43) | MAPTKDM4ESMN1; SMN2ALDH1A1APAF1 | |
| SCHEMBL16480415 | 0.84 | CXCR3 (0.45) | MAPTKDM4ESMN1; SMN2ALDH1A1APAF1 | |
| SCHEMBL16480405 | 0.84 | CXCR3 (0.45) | MAPTKDM4ESMN1; SMN2ALDH1A1APAF1 | |
| SCHEMBL9892972 | 0.82 | SMN1; SMN2 (0.44) | MAPTKDM4ESMN1; SMN2ALDH1A1APAF1 | |
| SCHEMBL9893158 | 0.82 | SMN1; SMN2 (0.44) | MAPTKDM4ESMN1; SMN2ALDH1A1APAF1 | |
| SCHEMBL9106786 | 0.78 | LMNA (0.46) | MAPTKDM4ESMN1; SMN2ALDH1A1ABL1 | |
| SCHEMBL9105531 | 0.78 | LMNA (0.46) | MAPTKDM4ESMN1; SMN2ALDH1A1ABL1 | |
| SCHEMBL3710780 | 0.78 | LMNA (0.46) | MAPTKDM4ESMN1; SMN2ALDH1A1ABL1 | |
| SCHEMBL9891497 | 0.78 | CNR2 (0.48) | MAPTKDM4ESMN1; SMN2ALDH1A1APAF1 | |
| SCHEMBL9891886 | 0.76 | SMN1; SMN2 (0.56) | MAPTSMN1; SMN2ALDH1A1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629157-B2 | Pyrrolidine compounds which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-14 | — | — | US | disclosed |
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | CNR2, CNR1, OPRL1 | MAPT 4057/4885KDM4E 2527/4885SMN1; SMN2 4659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.