Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16480384 | 0.81 | HSD11B1 (0.40) | CNR2HSD11B1NR1H2NR1H3DPP4 | |
| SCHEMBL9891501 | 0.78 | CNR2 (0.41) | CNR2HSD11B1NR1H2NR1H3HCRTR2 | |
| SCHEMBL9893039 | 0.78 | HSD11B1 (0.38) | CNR2HSD11B1NR1H2NR1H3DPP4 | |
| SCHEMBL9108329 | 0.77 | HSD11B1 (0.39) | CNR2HSD11B1NR1H2NR1H3DPP4 | |
| SCHEMBL9107204 | 0.77 | HSD11B1 (0.39) | CNR2HSD11B1NR1H2NR1H3DPP4 | |
| SCHEMBL9891826 | 0.75 | CNR2 (0.38) | CNR2HSD11B1NR1H2NR1H3MAPT | |
| SCHEMBL16253001 | 0.74 | CNR2 (0.44) | CNR2HSD11B1NR1H2NR1H3HCRTR2 | |
| SCHEMBL9891885 | 0.73 | PIK3CD (0.42) | CNR2HSD11B1NR1H2NR1H3DPP4 | |
| SCHEMBL9891830 | 0.73 | PIK3CD (0.42) | CNR2HSD11B1NR1H2NR1H3DPP4 | |
| SCHEMBL9892031 | 0.69 | CNR2 (0.73) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629157-B2 | Pyrrolidine compounds which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-14 | — | — | US | disclosed |
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | CNR2, CNR1, OPRL1 | CNR2 1/4885HSD11B1 3537/4885NR1H2 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.