Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9891869 | 0.81 | CNR2 (0.38) | HSD11B1MAPTCNR2NR1H2NR1H3 | |
| SCHEMBL9893039 | 0.81 | HSD11B1 (0.38) | HSD11B1MAPTCNR2NR1H2NR1H3 | |
| SCHEMBL9108329 | 0.81 | HSD11B1 (0.39) | HSD11B1CNR2NR1H2NR1H3DPP4 | |
| SCHEMBL9107204 | 0.81 | HSD11B1 (0.39) | HSD11B1CNR2NR1H2NR1H3DPP4 | |
| SCHEMBL9893109 | 0.73 | CNR2 (0.45) | HSD11B1MAPTGAATSHRCNR2 | |
| SCHEMBL16254878 | 0.72 | GAA (0.47) | HSD11B1MAPTGAATSHRCNR2 | |
| SCHEMBL26926002 | 0.72 | MAPT (0.59) | HSD11B1MAPTGAATSHRCNR2 | |
| SCHEMBL16480429 | 0.71 | MAPT (0.49) | HSD11B1MAPTGAATSHRCNR2 | |
| SCHEMBL16480374 | 0.71 | MAPT (0.49) | HSD11B1MAPTGAATSHRCNR2 | |
| SCHEMBL21358976 | 0.69 | DPP4 (0.39) | MAPTTSHRDPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629157-B2 | Pyrrolidine compounds which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-14 | — | — | US | disclosed |