Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.52 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.52 |
| ▸ | CCR2 | P41597 | 4/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852374 | 0.95 | MAPK1 (0.62) | MAPK1ALDH1A1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL13215732 | 0.87 | ALDH1A1 (0.57) | MAPK1ALDH1A1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL3572935 | 0.85 | ALDH1A1 (0.60) | MAPK1ALDH1A1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL25824759 | 0.85 | MAPK1 (0.55) | MAPK1ALDH1A1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL9892993 | 0.85 | MAPK1 (0.55) | MAPK1ALDH1A1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL11990426 | 0.85 | MAPK1 (0.54) | MAPK1ALDH1A1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL14395220 | 0.85 | MAPK1 (0.54) | MAPK1ALDH1A1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL4839403 | 0.83 | SPHK2 (0.52) | ALDH1A1SPHK2SPHK1CCR2TRPV6 | |
| SCHEMBL4848314 | 0.83 | SPHK2 (0.52) | ALDH1A1SPHK2SPHK1CCR2TRPV6 | |
| SCHEMBL4839388 | 0.83 | SPHK2 (0.52) | ALDH1A1SPHK2SPHK1CCR2TRPV6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142677-A1 | Pyrrolidine Compounds Which Modulate The CB2 Receptor | CNR2, CNR1, OPRL1 | MAPK1 1463/4885ALDH1A1 3279/4885CRHBP 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.