Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 5/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9893780 | 0.81 | TSHR (0.33) | MEN1KMT2APOLBTSHRMAPK1 | |
| SCHEMBL1437343 | 0.79 | KDM4E (0.40) | MEN1KMT2APOLBTSHRSMN1; SMN2 | |
| SCHEMBL9893812 | 0.74 | BCL9 (0.40) | MEN1KMT2APOLBMAPK1SMN1; SMN2 | |
| SCHEMBL1444984 | 0.73 | SMN1; SMN2 (0.31) | MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL9893874 | 0.69 | GABRA2 (0.52) | FAAH | |
| SCHEMBL1437246 | 0.69 | MEN1 (0.40) | MEN1KMT2APOLBSMN1; SMN2OPRK1 | |
| SCHEMBL1437489 | 0.69 | MEN1 (0.40) | MEN1KMT2ATSHRMAPK1SMN1; SMN2 | |
| SCHEMBL9893922 | 0.69 | MDM2 (0.44) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1437163 | 0.67 | OPRK1 (0.40) | MEN1KMT2APOLBRECQLSMN1; SMN2 | |
| SCHEMBL1437580 | 0.67 | MAPT (0.43) | MEN1KMT2APOLBMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | NOVARTIS AG (CH) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149661-A1 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS | MDM4, MDM2, TP53 | MEN1 510/4885KMT2A 1512/4885PTGDR2 4007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.