Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | VCP | P55072 | 7/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | KLK1 | P06870 | 5/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.40 |
| ▸ | DNM1L | O00429 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27855513 | 0.86 | KLK1 (0.46) | DRD2ACKR3VCPHTR2AHRH1 | |
| SCHEMBL985984 | 0.86 | KLK1 (0.46) | DRD2ACKR3VCPHTR2AHRH1 | |
| SCHEMBL12584712 | 0.79 | KLK1 (0.45) | DRD2DRD4ACKR3HTR2AHRH1 | |
| SCHEMBL12585687 | 0.77 | KLK1 (0.50) | DRD2ACKR3HTR2AHRH1KLK1 | |
| SCHEMBL985985 | 0.77 | KLK1 (0.43) | DRD2DRD4DRD3ACKR3HTR2A | |
| SCHEMBL12584717 | 0.77 | KLK1 (0.47) | DRD2DRD4DRD3KLK1KLKB1 | |
| SCHEMBL988224 | 0.76 | DRD2 (0.44) | DRD2ACKR3HTR2AHRH1KLK1 | |
| SCHEMBL985877 | 0.72 | KLK1 (0.58) | KLK1KLKB1DNM1L | |
| SCHEMBL12585769 | 0.71 | VCP (0.43) | VCP | |
| SCHEMBL12584698 | 0.71 | KLK1 (0.47) | KLK1KLKB1DNM1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2277858-A1 | AMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2011-01-26 | — | — | EP | disclosed |