Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 4/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | SGK1 | O00141 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | STK17B | O94768 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2905321 | 0.76 | KDM4E (0.42) | MEN1KMT2AALDH1A1HSD17B10GPR3 | |
| SCHEMBL989525 | 0.72 | KDM4E (0.41) | MEN1KMT2AALDH1A1HSD17B10GPR3 | |
| SCHEMBL5891207 | 0.71 | HSD17B10 (0.44) | MEN1KMT2AALDH1A1HSD17B10GPR3 | |
| SCHEMBL10973766 | 0.70 | KDM4E (0.48) | MEN1KMT2AALDH1A1HSD17B10GPR3 | |
| SCHEMBL4281532 | 0.70 | KDM4E (0.44) | MEN1KMT2AALDH1A1HSD17B10LMNA | |
| SCHEMBL4281540 | 0.70 | KDM4E (0.44) | MEN1KMT2AALDH1A1HSD17B10LMNA | |
| SCHEMBL31603757 | 0.68 | KDM4E (0.42) | MEN1KMT2AALDH1A1HSD17B10LMNA | |
| SCHEMBL7886462 | 0.64 | HPGD (0.40) | MEN1KMT2AALDH1A1HSD17B10LMNA | |
| SCHEMBL7886467 | 0.64 | HPGD (0.40) | MEN1KMT2AALDH1A1HSD17B10LMNA | |
| SCHEMBL10759873 | 0.64 | CDC25A (0.50) | MEN1KMT2AALDH1A1HSD17B10GPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448585-A1 | AZINONE-SUBSTITUTED AZEPINO[B]INDOLE AND PYRIDO-PYRROLO-AZEPINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF | Albany Molecular Research, Inc. (US) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011003005-A1 | AZINONE-SUBSTITUTED AZEPINO[B]INDOLE AND PYRIDO-PYRROLO-AZEPINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF | ALBANY MOLECULAR RESEARCH, INC. (US) | 2011-01-06 | — | — | WO | disclosed |