Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15317038 | 0.78 | NR1H2 (0.42) | CHRM2CHRM1CHRM3HSD17B10RECQL | |
| SCHEMBL8004785 | 0.78 | NR1H2 (0.42) | CHRM2CHRM1CHRM3HSD17B10RECQL | |
| SCHEMBL12660832 | 0.75 | NR1H2 (0.42) | CHRM2CHRM1CHRM3HSD17B10SMN1; SMN2 | |
| SCHEMBL1914633 | 0.75 | NR1H2 (0.42) | CHRM2CHRM1CHRM3HSD17B10SMN1; SMN2 | |
| SCHEMBL1914221 | 0.75 | NR1H2 (0.42) | CHRM2CHRM1CHRM3HSD17B10SMN1; SMN2 | |
| SCHEMBL116141 | 0.75 | NR1H2 (0.42) | CHRM2CHRM1CHRM3HSD17B10SMN1; SMN2 | |
| SCHEMBL19557223 | 0.75 | NR1H2 (0.42) | CHRM2CHRM1CHRM3HSD17B10SMN1; SMN2 | |
| SCHEMBL116548 | 0.75 | NR1H2 (0.42) | CHRM2CHRM1CHRM3HSD17B10SMN1; SMN2 | |
| SCHEMBL26791171 | 0.75 | NR1H2 (0.42) | CHRM2CHRM1CHRM3HSD17B10SMN1; SMN2 | |
| SCHEMBL23600171 | 0.72 | NR1H2 (0.41) | CHRM2CHRM1CHRM3HSD17B10RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2470525-A1 | PIPERIDINE DERIVATIVES USED AS OREXIN ANTAGONISTS | Glaxo Group Limited (GB) | 2012-07-04 | — | — | EP | disclosed |
| US-20120149723-A1 | 5-METHYL-PIPERIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF SLEEP DISORDER | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | US | disclosed |
| US-20120149711-A1 | PIPERIDINE DERIVATIVES USED AS OREXIN ANTAGONISTS | GLAXO GROUP LIMITED | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149711-A1 | PIPERIDINE DERIVATIVES USED AS OREXIN ANTAGONISTS | HCRTR2, HCRTR1, OXTR | CHRM2 778/4885CHRM1 666/4885CHRM3 557/4885 |
| US-20120149723-A1 | 5-METHYL-PIPERIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF SLEEP DISORDER | HCRTR2, HCRTR1, HTR5A | CHRM2 588/4885CHRM1 528/4885CHRM3 396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.