Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.48 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 5/20 | 0.43 |
| ▸ | MAOB | P27338 | 5/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.34 |
| ▸ | CHRNG | P07510 | 1/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CHRND | Q07001 | 1/20 | 0.34 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31368922 | 0.82 | KCNQ3 (0.39) | CES2CES1MAOAMAOBPTPN1 | |
| SCHEMBL16795682 | 0.81 | CES2 (0.50) | CES2CES1MAOAMAOBMEN1 | |
| SCHEMBL16795584 | 0.78 | CES2 (0.44) | CES2CES1PTPN1 | |
| SCHEMBL991185 | 0.78 | HTT (0.56) | MEN1KMT2AKCNQ3KCNQ2RAB9A | |
| SCHEMBL2175225 | 0.76 | PTPN1 (0.56) | CES2CES1MAOAMAOBPTPN1 | |
| SCHEMBL16953016 | 0.75 | CES2 (0.48) | CES2CES1MAOAMAOBPTPN1 | |
| SCHEMBL29628387 | 0.75 | PTPN1 (0.61) | CES2CES1PTPN1MEN1KMT2A | |
| SCHEMBL366866 | 0.75 | PTPN1 (0.61) | CES2CES1PTPN1MEN1KMT2A | |
| SCHEMBL991358 | 0.71 | GSK3B (0.56) | CES2CES1MAOAMAOBGSK3B | |
| SCHEMBL20938010 | 0.71 | CES2 (0.54) | CES2CES1MAOAMAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480080-A1 | PYRIDO[3,4-B]INDOLES AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2012-08-01 | — | — | EP | disclosed |
| WO-2011038163-A1 | PYRIDO[3,4-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2011-03-31 | — | — | WO | disclosed |
| EP-2274307-A1 | BRIDGED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009120720-A1 | BRIDGED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES,INC. (US) | 2009-10-01 | — | — | WO | disclosed |
| US-6025310-A | RETAINING STABILITY FREE OF HYDROLYSIS FOR PROLONGED PERIOD OF TIME, COMPATIBLE WITH ORGANIC LUBRICANTS HAVING BENZENE RING AND PHOSPHAZINE RING | KUBOTA CORPORATION (JP) | 2000-02-15 | — | — | US | disclosed |