Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 3/20 | 0.55 |
| ▸ | MAOB | P27338 | 3/20 | 0.55 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20146334 | 0.80 | GSK3B (0.45) | GSK3BMAOAMAOB | |
| SCHEMBL12318444 | 0.78 | PTPN1 (0.54) | TSHRALOX15CYP3A4MAPK1LMNA | |
| SCHEMBL2297994 | 0.78 | GSK3B (0.54) | GSK3BMAOAMAOBCES2CES1 | |
| SCHEMBL10673423 | 0.78 | MAOA (0.57) | GSK3BMAOAMAOBCES2CES1 | |
| SCHEMBL28445165 | 0.78 | GSK3B (0.58) | GSK3BCES2CES1ATMLMNA | |
| SCHEMBL13958953 | 0.76 | MAOA (0.55) | GSK3BMAOAMAOBCES2CES1 | |
| SCHEMBL2015853 | 0.76 | MAOA (0.55) | GSK3BMAOAMAOBCES2CES1 | |
| SCHEMBL2175225 | 0.76 | PTPN1 (0.56) | MAOAMAOBCES2CES1CA1 | |
| SCHEMBL990763 | 0.76 | TSHR (0.47) | MAOAMAOBTSHRMAPK1KDM4E | |
| SCHEMBL250821 | 0.75 | PTPN1 (0.52) | GSK3BMAOAMAOBCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111533698-B | 3-trifluoromethyl-5-aryl-1, 6-dihydropyridazine compound and preparation method thereof | 西北师范大学 | 2023-07-04 | — | — | CN | disclosed |
| US-20210059992-A1 | HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2021-03-04 | — | — | US | disclosed |
| US-10864201-B2 | Heteroaromatic compounds as Vanin inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-12-15 | — | — | US | disclosed |
| CN-111533698-A | 3-trifluoromethyl-5-aryl-1, 6-dihydropyridazine compound and preparation method thereof | 西北师范大学 | 2020-08-14 | — | — | CN | disclosed |
| WO-2020043658-A1 | HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-03-05 | — | — | WO | disclosed |
| US-20200069663-A1 | HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2020-03-05 | — | — | US | disclosed |
| US-9199929-B2 | Allyl ether-terminated fluoroalkanesulfinic acids, salts thereof, and a method of making the same | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2015-12-01 | — | — | US | disclosed |
| WO-2015087094-A1 | NEW ARYLALKENYLPROPARGYLAMINE DERIVATIVES EXHIBITING NEUROPROTECTIVE ACTION FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SEMMELWEIS EGYETEM (HU) | 2015-06-18 | — | — | WO | disclosed |
| WO-2014110298-A1 | 5-MEMBERED HETEROARYLS AND THEIR USE AS ANTIVIRAL AGENTS | GILEAD SCIENCES, INC. (US) | 2014-07-17 | — | — | WO | disclosed |
| US-20140088322-A1 | ALLYL ETHER-TERMINATED FLUOROALKANESULFINIC ACIDS, SALTS THEREOF, AND A METHOD OF MAKING THE SAME | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2014-03-27 | — | — | US | disclosed |
| EP-0212428-B1 | DIHYDROBENZO/B /THIOPHENES AND PHARMACEUTICAL COMPOSITIONS THEREOF USEFUL AS ANTIFUNGALS | SCHERING CORPORATION (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0281110-A2 | N-[2-(pyridyl)propyl]-N-substituted sulfonamide, herbicide containing the same as an active ingredient and intermediate thereof | MITSUBISHI KASEI CORPORATION (JP) | 1988-09-07 | — | — | EP | disclosed |
| US-4731364-A | Dihydrobenzo(B)thiophenes and pharmaceutical compositions thereof useful as antifungals | SCHERING CORPORATION (US) | 1988-03-15 | — | — | US | disclosed |
| EP-0212428-A1 | Dihydrobenzo/b /thiophenes and pharmaceutical compositions thereof useful as antifungals | SCHERING CORPORATION (US) | 1987-03-04 | — | — | EP | disclosed |
| EP-0148858-A1 | NOVEL TRIAZOLYL-SUBSTITUTED PROPANE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1985-07-24 | — | — | EP | disclosed |
| WO-1984004918-A1 | NOVEL TRIAZOLYL-SUBSTITUTED PROPANE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORP (US) | 1984-12-20 | — | — | WO | disclosed |
| EP-0127865-A1 | Novel triazolyl-substituted propane derivatives, their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-12-12 | — | — | EP | disclosed |
| US-4482564-A | FUNGICIDES | SCHERING CORPORATION (US) | 1984-11-13 | — | — | US | disclosed |
| EP-0122452-A1 | Triazolyl- and imidazolyl-substituted fluoroalkane derivatives, process for their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-10-24 | — | — | EP | disclosed |
| EP-0094167-A2 | Azolyl fungicide and plant growth regulators and compositions containing them | FBC LIMITED (GB) | 1983-11-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200069663-A1 | HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS | VHL, FANCI, PAH | GSK3B 1715/4885MAOA 331/4885MAOB 375/4885 |
| US-20210059992-A1 | HETEROAROMATIC COMPOUNDS AS VANIN INHIBITORS | VHL, FANCI, PAH | GSK3B 1715/4885MAOA 331/4885MAOB 375/4885 |
| US-10864201-B2 | Heteroaromatic compounds as Vanin inhibitors | VHL, FANCI, PAH | GSK3B 1715/4885MAOA 331/4885MAOB 375/4885 |
| US-20140088322-A1 | ALLYL ETHER-TERMINATED FLUOROALKANESULFINIC ACIDS, SALTS THEREOF, AND A METHOD OF MAKING THE SAME | TST, PFAS, ALAD | GSK3B 4793/4885MAOA 3451/4885MAOB 3759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.