Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.56 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 13/20 | 0.45 |
| ▸ | GSK3A | P49840 | 12/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900438 | 0.87 | RPS6KA3 (0.56) | RPS6KA3SLC22A12ALDH1A1ALOX15TSHR | |
| SCHEMBL16628650 | 0.76 | GPBAR1 (0.47) | GSK3BGSK3ATYK2TSHR | |
| SCHEMBL5106705 | 0.76 | ALDH1A1 (0.55) | MAPTALDH1A1TSHR | |
| SCHEMBL9915925 | 0.76 | LPAR1 (0.52) | RPS6KA3SLC22A12GSK3BGSK3AMAPT | |
| SCHEMBL27426524 | 0.75 | GSK3B (0.55) | GSK3BGSK3AMAPTALDH1A1ALOX15 | |
| SCHEMBL12496930 | 0.75 | GSK3A (0.55) | GSK3BGSK3AALDH1A1ALOX15TSHR | |
| SCHEMBL16702338 | 0.72 | ATR (0.52) | GSK3BGSK3AMAPT | |
| SCHEMBL5826769 | 0.72 | KDM4C (0.44) | GSK3BGSK3AMAPT | |
| SCHEMBL8946928 | 0.72 | TAAR1 (0.60) | GSK3BGSK3AMAPTTSHR | |
| SCHEMBL15770896 | 0.72 | PIK3C3 (0.44) | GSK3BGSK3AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648714-A2 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND USES THEREOF | Amira Pharmaceuticals, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078593-A2 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AND USES THEREOF | AMIRA PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | WO | disclosed |