Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 5/20 | 0.33 |
| ▸ | CNR2 | P34972 | 5/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16717622 | 0.84 | PTPN1 (0.34) | LMNAKDM4EALDH1A1PTPN1JAK2 | |
| SCHEMBL16717617 | 0.84 | PTPN1 (0.34) | LMNAKDM4EALDH1A1PTPN1JAK2 | |
| SCHEMBL16717445 | 0.79 | LMNA (0.36) | LMNAKDM4EALDH1A1PTPN1CNR1 | |
| SCHEMBL2218616 | 0.78 | TP53 (0.42) | TP53LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL16729397 | 0.78 | LMNA (0.43) | LMNAMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL16717058 | 0.78 | LMNA (0.43) | LMNAMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL9900871 | 0.77 | LMNA (0.36) | TP53LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL23041032 | 0.73 | LMNA (0.59) | TYRTP53LMNAMAPTKDM4E | |
| SCHEMBL16098438 | 0.73 | BACE1 (0.42) | TP53LMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL1177846 | 0.71 | GAA (0.59) | TP53LMNAMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649066-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |