Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.33 |
| ▸ | ICMT | O60725 | 1/20 | 0.33 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16717622 | 0.80 | PTPN1 (0.34) | LMNAKDM4ECYP1A2PTPN1SMN1; SMN2 | |
| SCHEMBL16717617 | 0.80 | PTPN1 (0.34) | LMNAKDM4ECYP1A2PTPN1SMN1; SMN2 | |
| SCHEMBL9900086 | 0.79 | TYR (0.36) | LMNAKDM4EPTPN1ALDH1A1CNR1 | |
| SCHEMBL16729397 | 0.77 | LMNA (0.43) | LMNAKDM4EPTPN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL16717058 | 0.77 | LMNA (0.43) | LMNAKDM4EPTPN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL28094796 | 0.75 | MEN1 (0.45) | LMNAKDM4ECYP1A2ADRB2ADRB1 | |
| SCHEMBL7892864 | 0.69 | PTPN1 (0.50) | LMNAKDM4EPTPN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL28866716 | 0.68 | L3MBTL1 (0.44) | LMNAKDM4ECYP1A2SMN1; SMN2L3MBTL1 | |
| SCHEMBL9901198 | 0.68 | PTPN1 (0.37) | KDM4EPTPN1L3MBTL1LTB4RLTB4R2 | |
| SCHEMBL9901199 | 0.68 | PTPN1 (0.45) | LMNAPTPN1HTTALDH1A1CAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071203-A2 | TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS | Forma Therapeutics, Inc. (US) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015074064-A2 | TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS | BAIR KENNETH W (US) | 2015-05-21 | — | — | WO | disclosed |