SCHEMBL990026 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	GRM5	P41594	12/20	0.43

▸	L3MBTL1	Q9Y468	1/20	0.39

▸	NPC1	O15118	2/20	0.38

▸	RAB9A	P51151	2/20	0.38

▸	CNR2	P34972	2/20	0.37

▸	USP2	O75604	1/20	0.36

▸	HPGD	P15428	1/20	0.36

▸	TSHR	P16473	1/20	0.36

▸	MEN1	O00255	1/20	0.35

▸	KMT2A	Q03164	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL990270	1.00	GRM5 (0.43)	GRM5L3MBTL1NPC1RAB9ACNR2
SCHEMBL991609	0.90	GRM5 (0.46)	GRM5
SCHEMBL3378678	0.87	GRM5 (0.44)	GRM5L3MBTL1NPC1RAB9A
SCHEMBL3373475	0.87	GRM5 (0.44)	GRM5L3MBTL1NPC1RAB9A
SCHEMBL990862	0.84	NPC1 (0.45)	GRM5L3MBTL1NPC1RAB9ACNR2
SCHEMBL992650	0.84	NPC1 (0.45)	GRM5L3MBTL1NPC1RAB9ACNR2
SCHEMBL990340	0.83	L3MBTL1 (0.59)	GRM5L3MBTL1NPC1RAB9AMEN1
SCHEMBL990196	0.82	CNR2 (0.48)	GRM5L3MBTL1NPC1RAB9ACNR2
SCHEMBL992298	0.82	CNR2 (0.48)	GRM5L3MBTL1NPC1RAB9ACNR2
SCHEMBL990125	0.81	GRM5 (0.57)	GRM5L3MBTL1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2272509-A1	New Uses of metabotropic glutamate receptors	Novartis AG (CH)	2011-01-12	—	—	EP	disclosed