Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 12/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992650 | 1.00 | NPC1 (0.45) | NPC1RAB9AKMT2ATP53SMN1; SMN2 | |
| SCHEMBL989508 | 0.90 | GRM5 (0.46) | NPC1RAB9AKMT2ATP53SMN1; SMN2 | |
| SCHEMBL990906 | 0.90 | GRM5 (0.46) | GRM5 | |
| SCHEMBL3376528 | 0.85 | GRM5 (0.44) | NPC1RAB9AKMT2ATP53SMN1; SMN2 | |
| SCHEMBL3378683 | 0.85 | GRM5 (0.44) | NPC1RAB9AKMT2ATP53SMN1; SMN2 | |
| SCHEMBL990757 | 0.84 | GRM5 (0.46) | NPC1RAB9AKMT2AGRM5L3MBTL1 | |
| SCHEMBL990736 | 0.84 | GRM5 (0.46) | NPC1RAB9AKMT2AGRM5L3MBTL1 | |
| SCHEMBL990026 | 0.84 | GRM5 (0.43) | NPC1RAB9AKMT2AGRM5L3MBTL1 | |
| SCHEMBL990270 | 0.84 | GRM5 (0.43) | NPC1RAB9AKMT2AGRM5L3MBTL1 | |
| SCHEMBL990125 | 0.83 | GRM5 (0.57) | NPC1RAB9ASMN1; SMN2GRM5L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2272509-A1 | New Uses of metabotropic glutamate receptors | Novartis AG (CH) | 2011-01-12 | — | — | EP | disclosed |