Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 4/20 | 0.37 |
| ▸ | SKP1 | P63208 | 4/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 4/20 | 0.37 |
| ▸ | SMO | Q99835 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15440818 | 0.85 | CKS1B (0.49) | CKS1BSKP1SKP2 | |
| SCHEMBL9900428 | 0.85 | LMNA (0.47) | USP2HPGDSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL31451849 | 0.75 | CKS1B (0.45) | USP2HPGDSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL9900933 | 0.72 | HPGD (0.54) | USP2HPGDSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL9900060 | 0.71 | CKS1B (0.51) | CKS1BSKP1SKP2LMNA | |
| SCHEMBL3282477 | 0.71 | — | — | |
| SCHEMBL5218581 | 0.69 | USP2 (0.51) | USP2HPGDSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL5218625 | 0.68 | USP2 (0.50) | USP2HPGDSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL5218982 | 0.68 | GBA1 (0.52) | USP2HPGDSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL5220298 | 0.68 | LMNA (0.46) | USP2HPGDSMN1; SMN2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9090593-B2 | Bicyclic compounds as Pim inhibitors | AMGEN INC. (US) | 2015-07-28 | — | — | US | disclosed |
| EP-2796456-A1 | Bicyclic compounds as Pim inhibitors | Amgen Inc. (US) | 2014-10-29 | — | — | EP | disclosed |
| US-20140031360-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2014-01-30 | — | — | US | disclosed |
| EP-2649065-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | Amgen Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078777-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | AMGEN INC. (US) | 2012-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031360-A1 | BICYCLIC COMPOUNDS AS PIM INHIBITORS | PIM1, PIM2, PIM3 | USP2 3563/4885HPGD 2221/4885SMN1; SMN2 4085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.