Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | FRK | P42685 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16105691 | 0.85 | SRC (0.37) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL3846787 | 0.78 | POLB (0.39) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL1554588 | 0.77 | CSNK1D (0.57) | MAPK14MAPK11MAPK13MAPK12CSNK1D | |
| SCHEMBL4313628 | 0.77 | ABCC8 (0.41) | ALDH1A1LMNAHTTMAPTPTGS2 | |
| SCHEMBL17777920 | 0.75 | MAPK14 (0.38) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL1648069 | 0.75 | MAPK14 (0.67) | MAPK14MAPK11MAPK13MAPK12CSNK1D | |
| SCHEMBL1555263 | 0.75 | MAPK14 (0.40) | KDM4EALDH1A1MAPK14MAPK11MAPK13 | |
| SCHEMBL2161744 | 0.74 | MAPK14 (0.38) | KDM4EALDH1A1SMN1; SMN2MAPK14MAPK11 | |
| SCHEMBL1554909 | 0.73 | NPC1 (0.44) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL29732965 | 0.73 | MAPK14 (0.45) | MAPK14MAPK11MAPK13MAPK12CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863310-B2 | Kinase inhibitors | ELI LILLY AND COMPANY (US) | 2011-01-04 | — | — | US | disclosed |