Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.36 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900537 | 0.87 | MEN1 (0.46) | MEN1TNFPOLBKMT2ANOD2 | |
| SCHEMBL9900841 | 0.83 | PLA2G7 (0.48) | GFERKDM4ETSHRPLA2G7GAA | |
| SCHEMBL9901291 | 0.83 | PLA2G7 (0.40) | MEN1TNFPOLBKMT2ANOD2 | |
| SCHEMBL9105504 | 0.82 | PLA2G7 (0.35) | MEN1TNFPOLBKMT2ANOD2 | |
| SCHEMBL9103266 | 0.79 | PLA2G7 (0.53) | PLA2G7 | |
| SCHEMBL9900524 | 0.77 | PLA2G7 (0.43) | MEN1KMT2AGFERKDM4ETSHR | |
| SCHEMBL9900226 | 0.76 | SLC22A12 (0.41) | MEN1KMT2AGFERKDM4ETSHR | |
| SCHEMBL9900606 | 0.75 | PLA2G7 (0.51) | MEN1TNFPOLBKMT2ANOD2 | |
| SCHEMBL9889612 | 0.73 | PLA2G7 (0.36) | MEN1TNFPOLBKMT2ANOD2 | |
| SCHEMBL9106220 | 0.72 | PLA2G7 (0.41) | PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649053-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | Glaxo Group Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076435-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |