Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 5/20 | 0.40 |
| ▸ | GFER | P55789 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900841 | 0.93 | PLA2G7 (0.48) | PLA2G7GFERKDM4ETSHRAR | |
| SCHEMBL9900226 | 0.91 | SLC22A12 (0.41) | PLA2G7GFERKDM4ETSHRSLC22A12 | |
| SCHEMBL9900537 | 0.88 | MEN1 (0.46) | PLA2G7GFERKDM4ETSHRLMNA | |
| SCHEMBL9901101 | 0.87 | PLA2G7 (0.53) | PLA2G7SLC22A12AR | |
| SCHEMBL9900524 | 0.84 | PLA2G7 (0.43) | PLA2G7GFERKDM4ETSHRAR | |
| SCHEMBL9900797 | 0.83 | MEN1 (0.39) | PLA2G7GFERKDM4ETSHRGAA | |
| SCHEMBL9105968 | 0.82 | PLA2G7 (0.41) | PLA2G7SLC22A12AR | |
| SCHEMBL9900408 | 0.80 | PLA2G7 (0.56) | PLA2G7AR | |
| SCHEMBL9902064 | 0.80 | SLC22A12 (0.42) | PLA2G7SLC22A12AR | |
| SCHEMBL9108200 | 0.80 | PLA2G7 (0.55) | PLA2G7SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649053-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | Glaxo Group Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076435-A1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2 | GLAXO GROUP LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |