Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9904722 | 0.81 | KDM4E (0.35) | CSNK1A1KDM4EALDH1A1MAPTMAPK1 | |
| SCHEMBL9900096 | 0.79 | POLB (0.46) | KDM4EALDH1A1MAPTMAPK1MEN1 | |
| SCHEMBL9900599 | 0.77 | — | — | |
| SCHEMBL9904673 | 0.65 | ADORA2A (0.35) | — | |
| SCHEMBL19703334 | 0.62 | PIK3CD (0.48) | KDM5B | |
| SCHEMBL9901079 | 0.62 | GLP1R (0.36) | — | |
| SCHEMBL9925837 | 0.62 | — | — | |
| SCHEMBL3550824 | 0.60 | L3MBTL1 (0.47) | ALDH1A1MAPK1MEN1KMT2ANPC1 | |
| SCHEMBL19105540 | 0.60 | PANK3 (0.39) | KDM5BKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL19105537 | 0.59 | POLB (0.41) | KDM5BALDH1A1MAPTMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012076966-A1 | SUBSTITUTED THIENO [3,4-B] PYRAZINE COMPOUNDS | LUPIN LIMITED (IN) | 2012-06-14 | — | — | WO | disclosed |
| WO-2012076966-A1 | SUBSTITUTED THIENO [3,4-B] PYRAZINE COMPOUNDS | LUPIN LIMITED (IN) | 2012-06-14 | — | — | WO | disclosed |