SCHEMBL9901461

SCHEMBL9901461

Cc1cccc(COc2c(C)c(C)n(-c3ccnc(-c4nc(C(C)(C)O)ncc4C)c3)c(=O)c2Cl)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPKAPK2 P49137 3/20 0.39
MAPKAPK5 Q8IW41 2/20 0.39
MAOB P27338 3/20 0.33
MAOA P21397 2/20 0.33
MRGPRX4 Q96LA9 2/20 0.33
THRA P10827 1/20 0.33
THRB P10828 1/20 0.33
BRD4 O60885 1/20 0.32
BRD9 Q9H8M2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C19 P33261 1/20 0.32
HTT P42858 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
HSP90AA1 P07900 1/20 0.32
PIK3CA P42336 1/20 0.31
MAPK1 P28482 1/20 0.31
MAPK14 Q16539 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9901821 0.93 THRA (0.34) MAPKAPK2MAPKAPK5MAOBMAOATHRA
SCHEMBL9112208 0.87 MAPKAPK5 (0.50) MAPKAPK2MAPKAPK5MAPK1MAPK14
SCHEMBL9901763 0.86 MAOB (0.35) MAOBMAOAMRGPRX4THRATHRB
SCHEMBL9110523 0.85 MAPKAPK5 (0.42) MAPKAPK2MAPKAPK5MAOBMAOAMRGPRX4
SCHEMBL9902078 0.84 MAPKAPK2 (0.38) MAPKAPK2MAPKAPK5MAOBMAOAMRGPRX4
SCHEMBL9905057 0.83 MAPKAPK2 (0.38) MAPKAPK2MAPKAPK5BRD4MAPK1MAPK14
SCHEMBL9113600 0.82 MAPK14 (0.44) MAPKAPK2MAPKAPK5MAPK14
SCHEMBL9110311 0.81 MAPKAPK2 (0.49) MAPKAPK2MAPKAPK5MAOBMAOAMAPK1
SCHEMBL9901669 0.80 MAOB (0.35) MAOBMAOATHRATHRBALDH1A1
SCHEMBL9902453 0.80 MAOB (0.36) MAOBMAOAALDH1A1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2648516-A1 SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS Confluence Life Sciences, Inc. (US) 2013-10-16 EP disclosed
WO-2012078684-A1 SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS CONFLUENCE LIFE SCIENCES, INC. (US) 2012-06-14 WO disclosed