SCHEMBL9901763

SCHEMBL9901763

Cc1cccc(COc2c(C)c(C)n(-c3ccnc(-c4nc(C(C)C)ncc4C)c3)c(=O)c2Cl)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 5/20 0.35
MAOA P21397 2/20 0.35
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C19 P33261 1/20 0.33
HTT P42858 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
BRD4 O60885 1/20 0.33
BRD9 Q9H8M2 1/20 0.33
HSP90AA1 P07900 1/20 0.33
THRA P10827 1/20 0.32
THRB P10828 1/20 0.32
MRGPRX4 Q96LA9 1/20 0.32
NPBWR1 P48145 1/20 0.32
MAPT P10636 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
CASR P41180 1/20 0.31
ACHE P22303 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9901669 0.94 MAOB (0.35) MAOBMAOAALDH1A1HSP90AA1THRA
SCHEMBL9901007 0.93 MAOB (0.34) MAOBMAOATHRATHRBMAPT
SCHEMBL9901769 0.92 MAOB (0.36) MAOBMAOAALDH1A1LMNACYP1A2
SCHEMBL9110474 0.87 MAPKAPK2 (0.39) MAOBMAOAALDH1A1LMNACYP1A2
SCHEMBL9905052 0.87 BRD4 (0.32) BRD4
SCHEMBL9901461 0.86 MAPKAPK2 (0.39) MAOBMAOAALDH1A1LMNACYP1A2
SCHEMBL9902538 0.85 MAOB (0.36) MAOBMAOAALDH1A1CYP1A2CYP3A4
SCHEMBL9905118 0.84 MAOB (0.37) MAOBMAOALMNATHRATHRB
SCHEMBL9901647 0.84 MAOB (0.35) MAOBMAOATHRATHRBMAPT
SCHEMBL9109600 0.84 MAPK14 (0.35) MAOBMAOAALDH1A1MRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2648516-A1 SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS Confluence Life Sciences, Inc. (US) 2013-10-16 EP claimed
WO-2012078684-A1 SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS CONFLUENCE LIFE SCIENCES, INC. (US) 2012-06-14 WO claimed
EP-2648516-A1 SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS Confluence Life Sciences, Inc. (US) 2013-10-16 EP disclosed
WO-2012078684-A1 SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS CONFLUENCE LIFE SCIENCES, INC. (US) 2012-06-14 WO disclosed