Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MASP2 | O00187 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.37 |
| ▸ | FEN1 | P39748 | 3/20 | 0.37 |
| ▸ | C1R | P00736 | 3/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10960503 | 0.80 | ALDH1A1 (0.48) | POLBALDH1A1SMN1; SMN2HTTC1R | |
| SCHEMBL990148 | 0.77 | POLB (0.47) | POLBALDH1A1SMN1; SMN2MASP2MEN1 | |
| SCHEMBL27645647 | 0.73 | POLB (0.49) | POLBALDH1A1SMN1; SMN2HTTALOX5AP | |
| SCHEMBL727229 | 0.71 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2MASP2MEN1NUDT1 | |
| SCHEMBL14365376 | 0.70 | MEN1 (0.44) | ALDH1A1MASP2MEN1NUDT1KMT2A | |
| SCHEMBL3287768 | 0.70 | ALDH1A1 (0.52) | POLBALDH1A1SMN1; SMN2MASP2MEN1 | |
| Hydrochloric Acid SCHEMBL28064763 | 0.69 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MASP2MEN1NUDT1 | |
| Hydrochloric Acid SCHEMBL27491088 | 0.69 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MASP2MEN1NUDT1 | |
| SCHEMBL25599218 | 0.69 | NR3C1 (0.53) | POLBALDH1A1SMN1; SMN2HTTALOX5AP | |
| SCHEMBL1201707 | 0.68 | TYMS (0.56) | POLBALDH1A1SMN1; SMN2MASP2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863310-B2 | Kinase inhibitors | ELI LILLY AND COMPANY (US) | 2011-01-04 | — | — | US | disclosed |
| US-20080227839-A1 | Kinase Inhibitors | ELI LILLY AND COMPANY | 2008-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227839-A1 | Kinase Inhibitors | ABL1, MAP3K20, MAP3K19 | POLB 1551/4885ALDH1A1 3631/4885SMN1; SMN2 3611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.