SCHEMBL9901715

SCHEMBL9901715

CCNS(=O)(=O)c1ccccc1OC(F)F

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.42
GLA P06280 1/20 0.42
CA12 O43570 3/20 0.40
CA9 Q16790 3/20 0.40
ALDH1A1 P00352 3/20 0.40
KDM4E B2RXH2 1/20 0.40
GAA P10253 1/20 0.40
PTGES2 Q9H7Z7 1/20 0.40
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
RAB9A P51151 1/20 0.39
ALOX5AP P20292 3/20 0.38
FEN1 P39748 3/20 0.38
TRPV4 Q9HBA0 1/20 0.38
HSD17B10 Q99714 1/20 0.38
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29572421 0.82 SLC22A12 (0.38) SLC22A12SMN1; SMN2GLAALDH1A1KDM4E
SCHEMBL168868 0.82 SLC22A12 (0.38) SLC22A12SMN1; SMN2GLAALDH1A1KDM4E
SCHEMBL28170661 0.82 SLC22A12 (0.50) SLC22A12SMN1; SMN2ALDH1A1PTGES2KMT2A
SCHEMBL31649956 0.76 TRPV4 (0.56) SLC22A12SMN1; SMN2CA12CA9ALDH1A1
SCHEMBL1610883 0.76 TRPV4 (0.56) SLC22A12SMN1; SMN2CA12CA9ALDH1A1
SCHEMBL10919538 0.75 SLC22A12 (0.47) SLC22A12SMN1; SMN2CA12CA9ALDH1A1
SCHEMBL10780698 0.75 SLC22A12 (0.47) SLC22A12SMN1; SMN2CA12CA9PTGES2
SCHEMBL11014404 0.75 SLC22A12 (0.44) SLC22A12SMN1; SMN2CA12CA9ALDH1A1
SCHEMBL9759823 0.74 SLC22A12 (0.44) SLC22A12CA9ALDH1A1KDM4EMEN1
SCHEMBL14488961 0.74 SLC22A12 (0.40) SLC22A12SMN1; SMN2KDM4EGAAPTGES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2648514-A1 INSECTICIDAL MIXTURES WITH IMPROVED PROPERTIES Bayer Intellectual Property GmbH (DE) 2013-10-16 EP disclosed
WO-2012076471-A1 INSECTICIDAL MIXTURES WITH IMPROVED PROPERTIES BAYER CROPSCIENCE AG (DE) 2012-06-14 WO disclosed