Sugi Predict

Sugi Predict / Compounds / SCHEMBL1610883

SCHEMBL1610883

SCHEMBL1610883

O=S(=O)(Cl)c1ccccc1OC(F)F

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPV4 Q9HBA0 3/20 0.56
▸ SLC22A12 Q96S37 1/20 0.47
▸ PTGES2 Q9H7Z7 1/20 0.42
▸ ELANE P08246 1/20 0.40
▸ DRD1 P21728 1/20 0.40
▸ KMT2A Q03164 2/20 0.38
▸ HTT P42858 2/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ ALDH1A1 P00352 3/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ CA1 P00915 2/20 0.35
▸ CA2 P00918 2/20 0.35
▸ CA12 O43570 1/20 0.35
▸ CA9 Q16790 1/20 0.35
▸ HTR6 P50406 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ ALOX12 P18054 1/20 0.34
▸ L3MBTL1 Q9Y468 2/20 0.33
▸ CA4 P22748 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31649956 1.00 TRPV4 (0.56) TRPV4SLC22A12PTGES2ELANEDRD1
SCHEMBL16835445 0.85 TRPV4 (0.45) TRPV4SLC22A12PTGES2ELANEKMT2A
SCHEMBL13692615 0.82 TRPV4 (0.50) TRPV4SLC22A12PTGES2ELANEDRD1
SCHEMBL1500968 0.81 IRAK4 (0.44) TRPV4PTGES2ELANEALDH1A1HSD17B10
SCHEMBL113890 0.81 SLC22A12 (0.47) TRPV4SLC22A12PTGES2ELANEDRD1
SCHEMBL31315370 0.81 PTGES2 (0.55) TRPV4SLC22A12PTGES2ELANEDRD1
SCHEMBL1622136 0.81 PTGES2 (0.55) TRPV4SLC22A12PTGES2ELANEDRD1
SCHEMBL10780900 0.81 SLC22A12 (0.47) TRPV4SLC22A12PTGES2ELANEDRD1
SCHEMBL646910 0.79 TRPV4 (0.47) TRPV4SLC22A12PTGES2ELANEMAPT
SCHEMBL22954617 0.78 HTR6 (0.61) TRPV4SLC22A12PTGES2ELANEDRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0064322-B1 BENZENESULFONYL ISOCYANATES, ISOTHIOCYANATES, CHLORIDES, AND SULFONAMIDES HAVING A FLUORINATED SUBSTITUENT E.I. DU PONT DE NEMOURS AND COMPANY (US) 1985-05-22 — — EP claimed
EP-0064322-A2 Benzenesulfonyl isocyanates, isothiocyanates, chlorides, and sulfonamides having a fluorinated substituent E.I. DU PONT DE NEMOURS AND COMPANY (US) 1982-11-10 — — EP claimed
CN-113795307-A Pyridopyrimidinyl compounds and methods of use thereof 基因泰克公司 2021-12-14 — — CN disclosed
US-10889555-B2 Sulfonamide compound or salt thereof TAIHO PHARMACEUTICAL CO., LTD. (JP) 2021-01-12 — — US disclosed
US-20200405697-A1 Antitumor Agent TAIHO PHARMACEUTICAL CO., LTD. (JP) 2020-12-31 — — US disclosed
US-20200399235-A1 Sulfonamide Compound or Salt Thereof TAIHO PHARMACEUTICAL CO., LTD. (JP) 2020-12-24 — — US disclosed
EP-3728194-A1 QUINOLINE SULFONAMIDE COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS Otago Innovation Limited (NZ) 2020-10-28 — — EP disclosed
EP-3718545-A1 ANTITUMOR AGENT Taiho Pharmaceutical Co., Ltd. (JP) 2020-10-07 — — EP disclosed
US-20200157066-A1 Sulfonamide Compound or Salt Thereof TAIHO PHARMACEUTICAL CO., LTD. (JP) 2020-05-21 — — US disclosed
EP-3466934-A1 SULFONAMIDE COMPOUND OR SALT THEREOF Taiho Pharmaceutical Co., Ltd. (JP) 2019-04-10 — — EP disclosed
WO-2017209155-A1 SULFONAMIDE COMPOUND OR SALT THEREOF 大鵬薬品工業株式会社 2017-12-07 — — WO disclosed
US-4521597-A PLANT GROWTH REGULATORS CIBA GEIGY CORPORATION (US) 1985-06-04 — — US disclosed
US-4518776-A VIA A SULFONYLCARBAMATE INTERMEDIATE, WITH AN AMINOTRIAZINE OR PYRIMIDINE CIBA GEIGY CORPORATION (US) 1985-05-21 — — US disclosed
EP-0121082-A1 Guanidin derivatives BAYER AG (DE) 1984-10-10 — — EP disclosed
US-4476321-A HERBICIDES, PLANT GROWTH REGULATORS CIBA-GEIGY CORPORATION (US) 1984-10-09 — — US disclosed
EP-0107624-A1 Process for the production of herbicidal and plant growth regulating sulfonyl ureas CIBA-GEIGY AG (CH) 1984-05-02 — — EP disclosed
EP-0101407-A2 Process for the preparation of herbicidal and plant growth regulating sulfonyl urea and sulfonyl carbamates as intermediates CIBA-GEIGY AG (CH) 1984-02-22 — — EP disclosed
EP-0044809-B1 N-(2-SUBSTITUTED PHENYLSULFONYL)-N'-TRIAZINYL UREAS CIBA-GEIGY AG (CH) 1983-08-31 — — EP disclosed
EP-0044808-A2 N-phenylsulfonyl-N'-pyrimidinyl- and -triazinyl ureas CIBA-GEIGY AG (CH) 1982-01-27 — — EP disclosed
EP-0044809-A1 N-(2-substituted phenylsulfonyl)-N'-triazinyl ureas CIBA-GEIGY AG (CH) 1982-01-27 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200399235-A1 Sulfonamide Compound or Salt Thereof RNASEH1, SNRPA1, RRM2 TRPV4 1831/4885SLC22A12 456/4885PTGES2 4338/4885
US-20200157066-A1 Sulfonamide Compound or Salt Thereof RNASEH1, SNRPA1, RRM2 TRPV4 1831/4885SLC22A12 456/4885PTGES2 4338/4885
US-10889555-B2 Sulfonamide compound or salt thereof RNASEH1, SNRPA1, RRM2 TRPV4 1831/4885SLC22A12 456/4885PTGES2 4338/4885
US-20200405697-A1 Antitumor Agent HNRNPR, RRM2, RRM2B TRPV4 3337/4885SLC22A12 568/4885PTGES2 4378/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.