Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992077 | 1.00 | GRM5 (0.44) | GRM5NPC1RAB9AL3MBTL1ACKR3 | |
| SCHEMBL990155 | 0.90 | GRM5 (0.47) | GRM5 | |
| SCHEMBL989481 | 0.90 | GRM5 (0.47) | GRM5 | |
| SCHEMBL990107 | 0.85 | ALDH1A1 (0.49) | GRM5NPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL992693 | 0.85 | GRM5 (0.46) | GRM5NPC1RAB9AL3MBTL1TRPV1 | |
| SCHEMBL990808 | 0.85 | ALDH1A1 (0.49) | GRM5NPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL991006 | 0.85 | GRM5 (0.46) | GRM5NPC1RAB9AL3MBTL1TRPV1 | |
| SCHEMBL3374797 | 0.85 | GRM5 (0.44) | GRM5NPC1RAB9AL3MBTL1 | |
| SCHEMBL3376064 | 0.85 | GRM5 (0.44) | GRM5NPC1RAB9AL3MBTL1 | |
| SCHEMBL990125 | 0.84 | GRM5 (0.57) | GRM5NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2272509-A1 | New Uses of metabotropic glutamate receptors | Novartis AG (CH) | 2011-01-12 | — | — | EP | disclosed |
| WO-2010000763-A2 | COMBINATION PRODUCTS | NOVARTIS AG (CH) | 2010-01-07 | — | — | WO | disclosed |