Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 2/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9901297 | 0.93 | BRD4 (0.31) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL9901203 | 0.92 | GABRG2 (0.30) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL9900820 | 0.91 | — | — | |
| SCHEMBL9902504 | 0.91 | GRM5 (0.32) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL9905118 | 0.86 | MAOB (0.37) | — | |
| SCHEMBL9112137 | 0.86 | MAPK14 (0.33) | GABRG2GABRB3GABRA5GABRA3GABRA2 | |
| SCHEMBL9902012 | 0.85 | — | — | |
| SCHEMBL9901254 | 0.85 | NMT1 (0.39) | — | |
| SCHEMBL9905454 | 0.85 | JMJD6 (0.33) | — | |
| SCHEMBL9905052 | 0.84 | BRD4 (0.32) | GABRG2GABRB3GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2648516-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | Confluence Life Sciences, Inc. (US) | 2013-10-16 | — | — | EP | claimed |
| WO-2012078684-A1 | SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | claimed |