Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL991427 | 0.90 | MAPK14 (0.50) | SPHK1MAPK14SMN1; SMN2ALDH1A1CSNK1D | |
| SCHEMBL990284 | 0.84 | MAPK14 (0.47) | MAPK14ALDH1A1LMNAHTTCSNK1D | |
| SCHEMBL4837575 | 0.76 | MAPK14 (0.72) | MAPK14CSNK1DEGFRCYP3A4ERBB2 | |
| SCHEMBL990285 | 0.76 | KDM4E (0.41) | MAPK14ALDH1A1CSNK1DMAPK13EGFR | |
| SCHEMBL4837487 | 0.74 | MAPK14 (0.41) | MAPK14CSNK1DMAPK13EGFRCSNK1E | |
| SCHEMBL5772806 | 0.72 | MAPK14 (0.76) | MAPK14CSNK1DEGFRCYP3A4ERBB2 | |
| SCHEMBL989412 | 0.72 | MAPK14 (0.41) | MAPK14ALDH1A1CSNK1DMAPK13EGFR | |
| SCHEMBL990654 | 0.71 | MAPK14 (0.55) | MAPK14SMN1; SMN2ALDH1A1HTTCSNK1D | |
| SCHEMBL4838938 | 0.71 | MAPK14 (0.41) | MAPK14CSNK1DMAPK13EGFRCSNK1E | |
| SCHEMBL4834028 | 0.71 | PIK3CA (0.52) | MAPK14SMN1; SMN2ALDH1A1LMNACSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863310-B2 | Kinase inhibitors | ELI LILLY AND COMPANY (US) | 2011-01-04 | — | — | US | disclosed |
| US-20080227839-A1 | Kinase Inhibitors | ELI LILLY AND COMPANY | 2008-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227839-A1 | Kinase Inhibitors | ABL1, MAP3K20, MAP3K19 | SPHK1 869/4885MAPK14 341/4885SMN1; SMN2 3611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.