Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.52 |
| ▸ | PI4KA | P42356 | 14/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 14/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 13/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.46 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | PIP5K1C | O60331 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4838938 | 0.88 | MAPK14 (0.41) | PIK3CAPI4KAPI4KBMAPK14MAPK13 | |
| SCHEMBL4837487 | 0.86 | MAPK14 (0.41) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL4837492 | 0.85 | MAPK14 (0.41) | PIK3CAPI4KAPI4KBMAPK14MAPK13 | |
| SCHEMBL991427 | 0.74 | MAPK14 (0.50) | MAPK14MAPK13EGFRCSNK1DCSNK1E | |
| SCHEMBL4837575 | 0.73 | MAPK14 (0.72) | PI4KBMAPK14EGFRCSNK1D | |
| SCHEMBL5748234 | 0.72 | MAPK14 (0.60) | MAPK14MAPK13EGFRCSNK1DCSNK1E | |
| SCHEMBL6212248 | 0.72 | PI4KA (0.53) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL8773471 | 0.71 | PIK3CA (1.00) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL990284 | 0.71 | MAPK14 (0.47) | MAPK14MAPK13EGFRCSNK1DCSNK1E | |
| SCHEMBL990252 | 0.71 | SPHK1 (0.45) | MAPK14MAPK13EGFRCSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320995-B2 | Benzimidazoles and benzothiazoles as inhibitors of map kinase | ELI LILLY AND COMPANY (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1554272-B1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | LILLY CO ELI (US) | 2006-10-25 | — | — | EP | disclosed |
| US-20050272791-A1 | Benzimidazoles and benzothiazoles as inhibitors of map kinase | EIL LILLY AND COMPANY (US) | 2005-12-08 | — | — | US | disclosed |
| EP-1554272-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004014900-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272791-A1 | Benzimidazoles and benzothiazoles as inhibitors of map kinase | MAP3K8, MAPK8, MAPK1 | PIK3CA 704/4885PI4KA 210/4885PI4KB 282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.