Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.54 |
| ▸ | KDR | P35968 | 10/20 | 0.53 |
| ▸ | BRAF | P15056 | 4/20 | 0.53 |
| ▸ | RAF1 | P04049 | 3/20 | 0.53 |
| ▸ | EGFR | P00533 | 5/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9903084 | 0.89 | BRAF (0.58) | EPHX2KDRBRAFRAF1EGFR | |
| SCHEMBL3768545 | 0.82 | BRAF (0.51) | KDRBRAFRAF1AURKANTRK2 | |
| SCHEMBL3836301 | 0.80 | KDR (0.54) | EPHX2KDRBRAFRAF1 | |
| SCHEMBL3761347 | 0.79 | CA12 (0.52) | KDRBRAFEGFRAURKAROCK2 | |
| SCHEMBL3767915 | 0.76 | BRAF (0.43) | KDRBRAFRAF1AURKAPDGFRA | |
| SCHEMBL3762938 | 0.74 | RET (0.60) | KDRBRAFAURKAROCK2LCK | |
| SCHEMBL2333691 | 0.74 | KDR (0.47) | KDRBRAFEGFRALDH1A1LCK | |
| SCHEMBL2333081 | 0.74 | ALDH1A1 (0.48) | KDRBRAFALDH1A1RETMAPT | |
| SCHEMBL3767003 | 0.74 | BRAF (0.42) | KDRBRAFRAF1EGFRLCK | |
| SCHEMBL3763732 | 0.72 | NTRK1 (0.43) | KDRBRAFRAF1EGFRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809629-B1 | N,N'-diphenyl urea derivatives suitable for the treatment of tumours, eye diseases, inflammation and diseases of the immune system | MERCK PATENT GMBH (DE) | 2012-06-13 | — | — | EP | claimed |